Also joining the duo in the squad is defender Jed Bews, who will make his debut if included in the final side to be announced Friday afternoon.
No Cats have been omitted from last week's side as yet.
THIS WEEK'S MEDICAL REPORT THANKS TO NIB
Simpson missed last week’s loss to Port Adelaide after rolling his ankle at training on ANZAC Day.
Motlop was included in the Cats squad last week before the club decided to give him one more run in the VFL.
SEE WHAT THE TIGERS ARE SAYING ABOUT THIS WEEK'S GAME
Bews has been on the Cats list since 2012 after being drafted as a father-son pick in the 2011 national draft.
The Cats head into the game with a five win and one loss record whilst the Tigers have just the two wins so far in 2014.
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Cats squad:
B: Rivers, Lonergan, Guthrie
HB: Enright, Taylor, Kelly
C: Horlin-Smith, Selwood, Johnson
HF: Varcoe, McIntosh, Murdoch
F: Duncan, Hawkins, Burbury
R: Simpson, Bartel, Stokes
IC: Bews, Blicavs, Hunt, Motlop, Sheringham, Thurlow, Walker
