Georgie Rankin has been named to face the Gold Coast Suns on Friday night.
The Round Five clash will take place at the Great Barrier Reef Arena in Mackey with the first bounce at 6.10pm local time.
Rankin comes in for Jordan Ivey after the on-baller received a one match suspension for a high bump on Tiger Katie Brennan.
Coach Paul Hood admits Ivey is a big loss for the Cats this week.
“It is going to be difficult because she is a really important part of the team, she is a great leader and a great part of our midfield,” Hood said.
Despite the absence of Ivey the Cats will enter their Round Five clash full of confidence after opening their account for the season with an impressive 22-point win against Richmond last weekend.
A victory against the Suns on Friday could see the Cats move up to fifth on the ladder if other results go their way.
Gold Coast have shown that they are a highly competitive outfit in the first half of the season and Hood knows the team will need to be at their best to prevail on Friday.
"Their form line is really good and we have to take them as an extremely competitive opponent."
The thing for us is we want to play that way every week no matter who we play."
"We won't change much about what we do, we just want to do it well."
Key Forward Phoebe McWilliams will reach her 25th AFLW game milestone after 14 games at the Giants prior to joining the Cats in their inaugural season.
AFLW Round Five Team
B: 19. Millie Brown, 24. Maddy McMahon
HB: 45. Maddy Keryk, 11. Meghan McDonald, 18. Melissa Hickey (c)
C: 9. Nina Morrison, 21. Rebecca Webster, 27. Sophie Van De Heuvel
HF: 12. Renee Garing, 23. Phoebe McWilliams, 2. Danielle Higgins
F: 30. Richelle Cranston, 8. Kate Darby
R: 14. Aasta O’Connor, 6. Julia Crockett-Grills, 16. Olivia Purcell
I/C: 3. Amy McDonald, 44. Rebecca Goring, 17. Georgia Clarke, 40. Anna Teague, 10. Georgie Rankin
EM: 4. Cassie Blakeway, 22. Nicole Garner
In: 10. Georgie Rankin
Out: 5. Jordan Ivey (suspended)